Trilo Therapeutics is focused on the discovery of novel inhibitors of protein-protein interactions for therapeutic purposes.

Our Trilomer™ platform of peptidomimetic binders allows for the targeted inhibition of disease-causing proteins, for the treatment of cancer, autoimmune diseases, infectious diseases, and others. In a revolution of therapeutic approaches, Trilomer™ peptidomimetic binders combine the cell permeability and degradation resistance of small molecules with the large surface area of antibodies, allowing them to target either intracellular and extracellular targets. Due to their fully synthetic modular building blocks, affinity optimization and structure-activity relationships (SAR) can be performed much more rapidly than either traditional medicinal chemistry or targeted mutagenesis of biologics.

 

Our Degradomer™ class of targeted protein degraders expands on the Trilomer™ concept, allowing highly specific degradation of disease-causing proteins, including so-called “undruggable” targets like K-Ras, β-catenin, FoxP3, and BIRC5/survivin.

 

Contact us at info@trilotx.com to purchase an evaluation kit, or to discuss your custom library screening project.

The 2019 price list of Trilomer™/Degradomer™ kits and large scale synthesis may be downloaded here.

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

 

© 2019  Trilo Therapeutics, Inc.